PMK Ethyl Glycidate (CAS 28578-16-7): Unraveling its Nature and Significance

Oct. 27, 2023

PMK Ethyl Glycidate (CAS 28578-16-7), known by its chemical name and CAS number, is a unique compound with a variety of applications, most notably in the field of chemistry and pharmaceuticals. This comprehensive guide aims to explore the nature, uses, and significance of PMK Ethyl Glycidate, shedding light on its chemical properties, synthesis, and the various industries it plays a pivotal role in.


 Understanding PMK Ethyl Glycidate


 Chemical Structure


PMK Ethyl Glycidate has the molecular formula C12H14O5 and a molecular weight of 238.24 g/mol. Its chemical structure consists of a phenyl ring with a methylenedioxy functional group (-O-CH2-O-) located in the meta position of the phenyl ring. It also has an ethyl glycinate group (-O-CH2-CHO-) attached to the meta position of the phenyl ring. This structure is fundamental to the compound's properties and reactivity.




PMK Ethyl Glycidate can be synthesized through various chemical processes, including the reaction of para-methoxyphenylacetic acid (PMPA) with an epoxide reagent. This reaction leads to the formation of PMK Ethyl Glycidate, which can be further purified for various applications.


 CAS Number


PMK Ethyl Glycidate is assigned the CAS (Chemical Abstracts Service) number 28578-16-7. This unique identifier facilitates the tracking and cataloging of chemical compounds, ensuring their accurate identification and usage in research and industry.




PMK Ethyl Glycidate finds applications in various industries and fields:


Chemical Synthesis: 

It serves as a key intermediate in the synthesis of different chemical compounds. PMK Ethyl Glycidate is used as a precursor in the production of substances such as MDMA (3,4-methylenedioxymethamphetamine) and MDA (3,4-methylenedioxyamphetamine), both of which belong to the amphetamine class of drugs.


Pharmaceutical Research: 

In the pharmaceutical industry, PMK Ethyl Glycidate may be used in research related to the development of potential new medications or drug formulations.


Flavor and Fragrance Industry:

It is sometimes used in the creation of specific flavors and fragrances due to its aromatic properties.


PMK Ethyl Glycidate (CAS 28578-16-7)

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 Pharmaceutical Significance


PMK Ethyl Glycidate, as a chemical precursor, plays a crucial role in pharmaceutical research and development. It serves as an intermediate compound in the synthesis of various pharmaceuticals and therapeutic agents. While PMK Ethyl Glycidate itself may not have direct pharmaceutical applications, it acts as a valuable building block for the creation of biologically active compounds.


 Chemical Research and Innovation


In the realm of chemical research, PMK Ethyl Glycidate is a valuable tool for scientists and researchers. Its unique chemical structure and reactivity make it an intriguing subject for investigations in the laboratory. Researchers may use PMK Ethyl Glycidate as a starting point for the development of new chemicals, pharmaceuticals, or materials.


 Regulatory Considerations


PMK Ethyl Glycidate, like many chemical compounds, is subject to regulatory oversight in various countries. Due to its potential use in the illicit synthesis of controlled substances, it may be subject to stringent regulations and restrictions. It is crucial for individuals and organizations working with PMK Ethyl Glycidate to be aware of and comply with the relevant laws and regulations in their jurisdiction.


 Illicit Uses and Control Measures


While PMK Ethyl Glycidate has legitimate applications in research and industry, it is unfortunately also associated with illicit activities. Illicit drug manufacturers have been known to use PMK Ethyl Glycidate as a precursor for the synthesis of controlled substances, including MDMA (3,4-methylenedioxymethamphetamine) and amphetamines.


To combat the illegal production of these substances, many countries have implemented strict regulations and control measures on the sale, distribution, and possession of PMK Ethyl Glycidate. These measures aim to limit its availability to illicit drug manufacturers and help curb the production of illegal drugs.


 Safety and Handling


As with any chemical compound, safety is of paramount importance when working with PMK Ethyl Glycidate. It is essential to follow appropriate safety protocols and procedures, including the use of personal protective equipment, adequate ventilation, and proper storage and handling practices.


Additionally, individuals and organizations involved in the synthesis or distribution of PMK Ethyl Glycidate must be aware of and comply with the legal and regulatory requirements specific to their region or country. Failure to do so can lead to severe legal consequences.




PMK Ethyl Glycidate (CAS 28578-16-7) is a chemical compound with diverse applications in pharmaceutical research, chemical innovation, and industry. Its unique chemical structure and reactivity make it a valuable tool for scientists and researchers. However, its association with illicit drug production has led to stringent regulations and control measures in many countries.


When used responsibly and in compliance with applicable laws and regulations, PMK Ethyl Glycidate can contribute to advancements in chemistry and medicine, ultimately benefiting society through the development of new pharmaceuticals and scientific knowledge.


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