The Lowest Price for 4-Piperidone!

4-Piperidone (CAS No. 79099-07-3) is a piperidine heterocyclic compound. Heterocyclic compounds are the most structurally important class of chemical substances, widely distributed in nature and widely used in pharmaceuticals, pesticides, dyes, and fine chemicals.

How is 4-piperidone synthesized?

Synthesis method an intermediate 4-piperidone synthesis method, including the following steps: (1) add β-alanine methyl ester to ethanol, put in a reaction kettle, add ethylene, mix well, cool down to 0 ℃, add PS-AlCl3-SbCl5 and sodium ethanol, stirring for reaction, after the reaction is completed, cool to room temperature, distillation at reduced pressure to remove ethanol; (2) add DMF to the reaction kettle and stirred and mixed well, heated to 110°C, reflux reaction under stirring conditions, after 1h reaction, lowered to room temperature, extracted with ethyl acetate, evaporated to remove ethyl acetate, followed by distillation under reduced pressure to produce said 4-piperidone. ps-AlCl3-SbCl5 is prepared by a method comprising the following steps: adding polystyrene powder to carbon tetrachloride, adding Chemicalbook Heat to 80°C, add AlCl3 and SbCl5, and carry out reflux reaction under stirring conditions, after the reaction is completed, reduce to room temperature, filter, wash, and dry to obtain said PS-AlCl3-SbCl5; wherein the mass fraction of AlCl3 is 10% and the mass fraction of SbCl5 is 7%. β-alanine methyl ester is used in a molar volume ratio of 1.1 to ethanol The molar ratio of β-alanine methyl ester to ethylene was 1:1.2; the mass ratio of β-alanine methyl ester to catalyst additive was 4:13; the molar ratio of β-alanine methyl ester to sodium ethanol was 9:7; the volume ratio of DMF to ethanol was 1:1. The yield of 4-piperidone was 91.7%.

Upstream and downstream products of 4-piperidone

Upstream raw materials

●Sodium hydride

●Toluene

●Potassium carbonate

●Benzamide

●Ethyl Acrylate Hydrochloric Acid

Downstream products

●1-Benzyl-3-carbomethoxy-4-piperidone hydrochloride

●4-Piperidone ethylene glycol

●1-Cbz-4-piperidone

Ethyl (1-benzylpiperidine-4-yl)acetate

●N-Carbomethoxy-4-piperidone

Methyl 4-hydroxypiperidine-1-carboxylate

tert-butyl 1-oxo-2,8-diazaspiro[4,5]decane-8-carboxylate

●N-propyl-4-piperidone

●N-acetyl-4-piperidone

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